run up against造句

Don't back up the moment you run up against a little difficulty.
不要遇到一点困难就打退堂鼓.

This is one of the most puzzling cases I have ever run up against.
这是我经手的最难办的案件之一.

When our principles run up against our interests, which should we adhere to?
当我们的原则和自身利益互相冲突时, 我们应该服从哪一方 呢 ?

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