“大挫折”用英语怎么说?

“大挫折”的英语可以翻译为:
looper
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    一件事过于顺利的时候, 很可能不久就会有大挫折.When anything goes this well, a major setback can be just around the corner.可是我遭受了一次大挫折.But I have had a Bad setBack....